U-M researchers find new applications for cancer drug
University of Michigan,
11/29/2007
University of Michigan scientists have found that a drug used to treat advanced multiple myeloma may have another use - pushing cancer cells into overdrive, then burn out.
Excerpt:
The U-M scientists found that bortezomib, a drug approved by the FDA to treat advanced multiple myeloma, is able to selectively inhibit melanoma tumor cells because it causes the c-MYC oncogene to overproduce a cell-death promoter called NOXA. Their results place c-MYC and NOXA, well studied among cancer researchers, in a new light. The study appears online ahead of print in the Proceedings of the National Academy of Sciences.
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